Cruzalegui, F : rechercher sur Z-Library

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1

546 The PI3Kbeta/delta inhibitor AZD8186 combines with the dual mTORC1/2 inhibitor AZD2014 to give comprehensive PI3K pathway inhibition and drive tumour regression in vivo

Simon, B., Hancox, U., Polanska, U., Hanson, L., Dudley, P., Ellston, R., Maynard, J., Kraus, M., Curwen, J., Klinowska, T., Ward, L., Cruzalegui, F., Symeonides, S., Cronin, K.

Journal:

European Journal of Cancer

Année:

2014

Langue:

english

Fichier:

PDF, 58 KB

english, 2014

2

AZD8186 study 1: Phase I study to assess the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and preliminary anti-tumour activity of AZD8186 in patients with advanced castration-resistant prostate cancer (CRPC), squamous non-small cell lung cancer, triple negative breast cancer and with PTEN-deficient/mutated or PIK3CB mutated/amplified malignancies, as monotherapy and in combination with vistusertib (AZD2014) or abiraterone acetate

Lillian, S., De Bono, J., Higano, C., Shapiro, G., Brugger, W., Mitchell, P., Colebrook, S., Klinowska, T., Barry, S., Dean, E., Martin-Mills, J., Wisinski, K., Moorthy, G., Mills, J., Cruzalegui, F.,

Journal:

European Journal of Cancer

Année:

2016

Langue:

english

Fichier:

PDF, 53 KB

english, 2016

3

Argentina: Problemas Macroeconómicos, Conflicto Social y Debilitamiento de la Coalición de Gobierno

LEIRAS, MARCELO, CRUZALEGUI, INÉS

Journal:

Revista de ciencia política (Santiago)

Année:

2009

Fichier:

PDF, 348 KB

2009

4

Synthesis, in vitro antiproliferative activities, and Chk1 inhibitory properties of indolylpyrazolones and indolylpyridazinedione

Elisabeth Conchon, Bettina Aboab, Roy M. Golsteyn, Francisco Cruzalegui, Thomas Edmonds, Stéphane Léonce, Bruno Pfeiffer, Michelle Prudhomme

Journal:

European Journal of Medicinal Chemistry

Année:

2006

Langue:

english

Fichier:

PDF, 449 KB

english, 2006

5

Calcium-regulated protein kinase cascades and their transcription factor targets

F. H. Cruzalegui, H. Bading *

Journal:

Cellular and Molecular Life Sciences

Année:

2000

Langue:

english

Fichier:

PDF, 84 KB

english, 2000

6

Synthesis and pharmacological evaluation of thieno[2,3-b]pyridine derivatives as novel c-Src inhibitors

Isabelle Pevet, Cédric Brulé, André Tizot, Arnaud Gohier, Francisco Cruzalegui, Jean A. Boutin, Solo Goldstein

Journal:

Bioorganic & Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 1.01 MB

english, 2011

7

Calmodulin-dependent protein kinase II mediates inactivation of MPF and CSF upon fertilization of Xenopus eggs

Lorca, Thierry, Cruzalegui, Francisco H., Fesquet, Didier, Cavadore, Jean-claude, Méry, Jean, Means, Anthony, Dorée, Marcel

Journal:

Année:

1993

Fichier:

PDF, 534 KB

1993

8

Src family tyrosine kinases-driven colon cancer cell invasion is induced by Csk membrane delocalization

Sirvent, A, Bénistant, C, Pannequin, J, Veracini, L, Simon, V, Bourgaux, J-F, Hollande, F, Cruzalegui, F, Roche, S

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 996 KB

english, 2009

9

ERK activation induces phosphorylation of Elk-1 at multiple S/T-P motifs to high stoichiometry

Cruzalegui, Francisco H, Cano, Eva, Treisman, Richard

Journal:

Année:

2000

Langue:

english

Fichier:

PDF, 715 KB

english, 2000

10

Src kinase phosphorylates vascular endothelial-cadherin in response to vascular endothelial growth factor: identification of tyrosine 685 as the unique target site

Wallez, Y, Cand, F, Cruzalegui, F, Wernstedt, C, Souchelnytskyi, S, Vilgrain, I, Huber, P

Journal:

Année:

2006

Langue:

english

Fichier:

PDF, 310 KB

english, 2006

11

c-Jun functions as a calcium-regulated transcriptional activator in the absence of JNK/SAPK1 activation

Cruzalegui, F. H.

Journal:

The EMBO Journal

Année:

1999

Langue:

english

Fichier:

PDF, 460 KB

english, 1999

12

Mechanisms controlling gene expression by nuclear calcium signals

Giles E. Hardingham, Francisco H. Cruzalegui, Sangeeta Chawla, Hilmar Bading

Journal:

Année:

1998

Langue:

english

Fichier:

PDF, 918 KB

english, 1998

13

A novel non-phosphorylated potential antitumoral peptide inhibits STAT3 biological activity

Jennifer Dourlat, Wang-Qing Liu, Florence Sancier, Thomas Edmonds, Perayot Pamonsinlapatham, Francisco Cruzalegui, Christiane Garbay

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 417 KB

english, 2009

14

Control of Recruitment and Transcription-Activating Function of CBP Determines Gene Regulation by NMDA Receptors and L-Type Calcium Channels

Giles E. Hardingham, Sangeeta Chawla, Francisco H. Cruzalegui, Hilmar Bading

Journal:

Année:

1999

Langue:

english

Fichier:

PDF, 358 KB

english, 1999

15

576 Integrative Approaches for the Identification of Therapeutic Targets in Basal-like Breast Cancer From Multi-level Molecular Data

B.M. Tesson, G. Rigaill, D. Gentien, S. Roman-Roman, F. Cruzalegui, S. Depil, A. Pierre, G. Tucker, T. Dubois, E. Barillot

Journal:

European Journal of Cancer

Année:

2012

Langue:

english

Fichier:

PDF, 57 KB

english, 2012

16

Up-regulated PI3K signalling pathway in basal-like breast carcinomas

B. Marty, E. Gravier, G. Rigaill, A. Vincent-Salomon, I. Lebigot, F. Cruzalegui, G.C. Tucker, J.P. Thiery, J.A. Hickman, T. Dubois

Journal:

European Journal of Cancer Supplements

Année:

2008

Langue:

english

Fichier:

PDF, 85 KB

english, 2008

17

Synthesis and primary cytotoxicity evaluation of arylmethylenenaphthofuranones derivatives

Lardic, Morgane, Patry, Cedric, Duflos, Muriel, Guillon, Jean, Massip, Stephane, Cruzalegui, Francisco, Edmonds, Thomas, Giraudet, Stephanie, Marini, Laetitia, Leonce, Stephane

Journal:

Journal of Enzyme Inhibition and Medicinal Chemistry

Année:

2006

Langue:

english

Fichier:

PDF, 341 KB

english, 2006

18

Protein kinases: From targets to anti-cancer drugs

Journal:

Annales Pharmaceutiques Françaises

Année:

2010

Fichier:

PDF, 665 KB

2010

19

524 LRP5: a Potential Therapeutic Target in Triple-negative Breast Cancer

Maubant, S., Maire, V., Tesson, B., Gentien, D., Marty-Prouvost, B., Cruzalegui, F., Depil, S., Tucker, G.C., Roman-Roman, S., Dubois, T.

Journal:

European Journal of Cancer

Année:

2012

Langue:

english

Fichier:

PDF, 128 KB

english, 2012

20

Editorial overview: Cancer: From target discovery to targeted therapy: the risky business of target validation

Cruzalegui, Francisco

Journal:

Current Opinion in Pharmacology

Année:

2014

Langue:

english

Fichier:

PDF, 178 KB

english, 2014

21

A review of policy debates around learning in the post-2015 education and development agenda

Winthrop, Rebecca, Anderson, Kate, Cruzalegui, Inés

Journal:

International Journal of Educational Development

Année:

2015

Langue:

english

Fichier:

PDF, 552 KB

english, 2015

22

Design, synthesis and evaluation of new 6-substituted-5-benzyloxy-4-oxo- 4H -pyran-2-carboxamides as potential Src inhibitors

Farard, Julien, Lanceart, Gaëtan, Logé, Cedric, Nourrisson, Marie-Renée, Cruzalegui, Francisco, Pfeiffer, Bruno, Duflos, Muriel

Journal:

Journal of Enzyme Inhibition and Medicinal Chemistry

Année:

2008

Langue:

english

Fichier:

PDF, 277 KB

english, 2008

23

Sequence of the cDNA for the alpha subunit of calmodulin kinase II from mouse brain

Hanley, R.M., Payne, M.E., Cruzalegui, F., Christenson, M.A., Means, A.R.

Journal:

Nucleic Acids Research

Année:

1989

Langue:

english

Fichier:

PDF, 60 KB

english, 1989

24

Regulation of Intrasteric Inhibition of the Multifunctional Calcium/ Calmodulin-Dependent Protein Kinase

Francisco H. Cruzalegui, Michael S. Kapiloff, John-Paul Morfin, Bruce E. Kemp, Michael G. Rosenfeld and Anthony R. Means

Journal:

Proceedings of the National Academy of Sciences

Année:

1992

Langue:

english

Fichier:

PDF, 1.14 MB

english, 1992

25

Defining actionable mutations for oncology therapeutic development

Carr, T. Hedley, McEwen, Robert, Dougherty, Brian, Johnson, Justin H., Dry, Jonathan R., Lai, Zhongwu, Ghazoui, Zara, Laing, Naomi M., Hodgson, Darren R., Cruzalegui, Francisco, Hollingsworth, Simon J

Journal:

Nature Reviews Cancer

Année:

2016

Langue:

english

Fichier:

PDF, 342 KB

english, 2016

26

A novel Ca2+/calmodulin-dependent protein kinase and a male germ cell-specific calmodulin-binding protein are derived from the same gene.

Means, A R, Cruzalegui, F, LeMagueresse, B, Needleman, D S, Slaughter, G R, Ono, T

Journal:

Molecular and Cellular Biology

Année:

1991

Langue:

english

Fichier:

PDF, 3.15 MB

english, 1991

27

Regulation of intrasteric inhibition of the multifunctional calcium/calmodulin-dependent protein kinase.

Cruzalegui, F. H., Kapiloff, M. S., Morfin, J. P., Kemp, B. E., Rosenfeld, M. G., Means, A. R.

Journal:

Proceedings of the National Academy of Sciences

Année:

1992

Langue:

english

Fichier:

PDF, 1.50 MB

english, 1992

28

CONTROL OF RECRUITMENT AND ACTIVATION OF CBP DETERMINES GENE REGULATION BY NMDA RECEPTORS AND L-TYPE CALCIUM CHANNELS

Hardingham, Giles E., Chawla, Sangeeta, Cruzalegui, Francisco H., Bading, Hilmar

Journal:

Biochemical Society Transactions

Année:

1999

Langue:

english

Fichier:

PDF, 142 KB

english, 1999

29

Edad como factor de riesgo para desarrollar síndrome metabólico en trabajadores mineros a gran altura

Mejia, Christian R., Quiñones-Laveriano, Dante M., Cruzalegui-Solari, Claudia C., Arriola-Quiroz, Isaias, Perez-Perez, Luís, Gomero, Raul

Journal:

Revista Argentina de Endocrinología y Metabolismo

Année:

2016

Fichier:

PDF, 716 KB

2016

30

Structure-Based Design and Synthesis of Harmine Derivatives with Different Selectivity Profiles in Kinase versus Monoamine Oxidase Inhibition

Bálint, Balázs, Wéber, Csaba, Cruzalegui, Francisco, Burbridge, Mike, Kotschy, Andras

Journal:

Année:

2017

Langue:

english

Fichier:

PDF, 1.52 MB

english, 2017

31

Endoscopic Treatment for Vesicoureteral Reflux in Recurrent Urinary Tract Infections in Kidney Transplant: Experience of One Center

Gomez Lujan, M., Velarde, L., Cruzalegui, C., Berrios, C., Sifuentes, E., Gálvez, J., Soto, H., Castañeda, E., Bazán, G., Nakachi, A., Chambi, M., Medina, C., Torres, A.

Journal:

Transplantation Proceedings

Année:

2018

Langue:

english

Fichier:

PDF, 528 KB

english, 2018

32

443TiPFirst-in-human trial design for W0101: A first-in-class antibody-drug conjugate targeting IGF-1R and identification of the target patient population

Gomez-Roca, C A, Garralda-Cabanas, E, Cruzalegui, F, Ausseil, F, Zorza, G, Delfour, O, Besse, J, Akla, B, Gautier, S, Adam, J, Lacroix-Triki, M, Passioukov, A, Roche, R, Pavlyuk, M, Massard, C

Journal:

Annals of Oncology

Année:

2018

Langue:

english

Fichier:

PDF, 93 KB

english, 2018

33

The p38 and ERK MAP kinase pathways cooperate to activate Ternary Complex Factors and c-fos transcription in response to UV light.

Price, M. A., Cruzalegui, F. H., Treisman, R.

Journal:

The EMBO Journal

Année:

1996

Langue:

english

Fichier:

PDF, 3.39 MB

english, 1996

34

Cojoined twins thoracoonfalophagus separation and liver bipartition (case report)

Torres, V.H., Anchante, E., Yeren, C.M., Nuñez, J.J., Cruzalegui, R., Rivera, A Fuentes, Ludeña, W., Arboleda, M., Chavarry, F., Palma, L., Chumpitazi, S., Cabana, L., Cabrera, W., Mucha, J., Villegas

Journal:

Année:

2019

Langue:

english

Fichier:

PDF, 281 KB

english, 2019

35

Cojoined twins thoracoonfalophagus separation and liver bipartition (case report)

Torres, V.H., Anchante, E., Yeren, C.M., Nuñez, J.J., Cruzalegui, R., Rivera, A Fuentes, Ludeña, W., Arboleda, M., Chavarry, F., Palma, L., Chumpitazi, S., Cabana, L., Cabrera, W., Mucha, J., Villegas

Journal:

Année:

2019

Fichier:

PDF, 281 KB

2019

36

SP766LEVEL OF TACROLIMUS AND CLINICAL OUTCOMES IN KIDNEY TRANSPLANT RECIPIENTS IN A SINGLE CENTER. LIMA PERU

Bazan, Giannina, Berrios, Carmen, Castañeda, Evelyn, Chambi, Maria, Cruzalegui, Cesar, Galvez, Jungmei, Gomez, Martin, Mendoza, Rodolfo, Nakachi, Augusto, Sifuentes, Ester, Soto, Heinrich

Journal:

Nephrology Dialysis Transplantation

Année:

2017

Langue:

english

Fichier:

PDF, 73 KB

english, 2017

37

SUN-292 KNOWLEDGE AND ATTITUDE TOWARDS ORGAN DONATION AMONG PERUVIAN MEDICAL RESIDENTS

GOMEZ LUJAN MD, M., Cruzalegui, C., Nakachi, A., Soto, H., Pastor MD, A.C.

Journal:

Kidney International Reports

Année:

2020

Fichier:

PDF, 123 KB

2020